Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin

[Image: see text] As a result of its higher molecular mobility, the surface of an amorphous drug can grow crystals much more rapidly than the bulk, causing poor stability and slow dissolution of drug products. We show that a nanocoating of chitosan (a pharmaceutically acceptable polymer) can be depo...

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Autores principales: Li, Yuhui, Yu, Junguang, Hu, Shenye, Chen, Zhenxuan, Sacchetti, Mark, Sun, Changquan Calvin, Yu, Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404105/
https://www.ncbi.nlm.nih.gov/pubmed/30668120
http://dx.doi.org/10.1021/acs.molpharmaceut.8b01237
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author Li, Yuhui
Yu, Junguang
Hu, Shenye
Chen, Zhenxuan
Sacchetti, Mark
Sun, Changquan Calvin
Yu, Lian
author_facet Li, Yuhui
Yu, Junguang
Hu, Shenye
Chen, Zhenxuan
Sacchetti, Mark
Sun, Changquan Calvin
Yu, Lian
author_sort Li, Yuhui
collection PubMed
description [Image: see text] As a result of its higher molecular mobility, the surface of an amorphous drug can grow crystals much more rapidly than the bulk, causing poor stability and slow dissolution of drug products. We show that a nanocoating of chitosan (a pharmaceutically acceptable polymer) can be deposited on the surface of amorphous indomethacin by electrostatic deposition, leading to significant improvement of physical stability, wetting by aqueous media, dissolution rate, powder flow, and tabletability. The coating condition was chosen so that the positively charged polymer deposits on the negatively charged drug. Chitosan coating is superior to gelatin coating with respect to stability against crystallization and agglomeration of coated particles.
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spelling pubmed-64041052019-03-08 Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin Li, Yuhui Yu, Junguang Hu, Shenye Chen, Zhenxuan Sacchetti, Mark Sun, Changquan Calvin Yu, Lian Mol Pharm [Image: see text] As a result of its higher molecular mobility, the surface of an amorphous drug can grow crystals much more rapidly than the bulk, causing poor stability and slow dissolution of drug products. We show that a nanocoating of chitosan (a pharmaceutically acceptable polymer) can be deposited on the surface of amorphous indomethacin by electrostatic deposition, leading to significant improvement of physical stability, wetting by aqueous media, dissolution rate, powder flow, and tabletability. The coating condition was chosen so that the positively charged polymer deposits on the negatively charged drug. Chitosan coating is superior to gelatin coating with respect to stability against crystallization and agglomeration of coated particles. American Chemical Society 2019-01-22 2019-03-04 /pmc/articles/PMC6404105/ /pubmed/30668120 http://dx.doi.org/10.1021/acs.molpharmaceut.8b01237 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Li, Yuhui
Yu, Junguang
Hu, Shenye
Chen, Zhenxuan
Sacchetti, Mark
Sun, Changquan Calvin
Yu, Lian
Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin
title Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin
title_full Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin
title_fullStr Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin
title_full_unstemmed Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin
title_short Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin
title_sort polymer nanocoating of amorphous drugs for improving stability, dissolution, powder flow, and tabletability: the case of chitosan-coated indomethacin
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404105/
https://www.ncbi.nlm.nih.gov/pubmed/30668120
http://dx.doi.org/10.1021/acs.molpharmaceut.8b01237
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