CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain

BACKGROUND: Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. However, mitochondria are required for intracellular oxygenation and normal physi...

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Detalles Bibliográficos
Autores principales: Thomas, Luke W., Stephen, Jenna M., Esposito, Cinzia, Hoer, Simon, Antrobus, Robin, Ahmed, Afshan, Al-Habib, Hasan, Ashcroft, Margaret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404347/
https://www.ncbi.nlm.nih.gov/pubmed/30886710
http://dx.doi.org/10.1186/s40170-019-0194-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404347/
https://www.ncbi.nlm.nih.gov/pubmed/30886710
http://dx.doi.org/10.1186/s40170-019-0194-y

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