Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists

Macrocycles were designed to antagonize the protein–protein interaction p53-MDM2 based on the three-finger pharmacophore F(19)W(23)L(25). The synthesis was accomplished by a rapid, one-pot synthesis of indole-based macrocycles based on Ugi macrocyclization. The reaction of 12 different α,ω-amino aci...

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Detalles Bibliográficos
Autores principales: Neochoritis, Constantinos G, Kazemi Miraki, Maryam, Abdelraheem, Eman M M, Surmiak, Ewa, Zarganes-Tzitzikas, Tryfon, Łabuzek, Beata, Holak, Tad A, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404402/
https://www.ncbi.nlm.nih.gov/pubmed/30873235
http://dx.doi.org/10.3762/bjoc.15.45

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404402/
https://www.ncbi.nlm.nih.gov/pubmed/30873235
http://dx.doi.org/10.3762/bjoc.15.45

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