Thiol-free chemoenzymatic synthesis of β-ketosulfides

A preparation of β-ketosulfides avoiding the use of thiols is described. The combination of a multicomponent reaction and a lipase-catalysed hydrolysis has been developed in order to obtain high chemical diversity employing a single sulfur donor. This methodology for the selective synthesis of a set...

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Detalles Bibliográficos
Autores principales: Heredia, Adrián A, López-Vidal, Martín G, Kurina-Sanz, Marcela, Bisogno, Fabricio R, Peñéñory, Alicia B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404416/
https://www.ncbi.nlm.nih.gov/pubmed/30873224
http://dx.doi.org/10.3762/bjoc.15.34
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author Heredia, Adrián A
López-Vidal, Martín G
Kurina-Sanz, Marcela
Bisogno, Fabricio R
Peñéñory, Alicia B
author_facet Heredia, Adrián A
López-Vidal, Martín G
Kurina-Sanz, Marcela
Bisogno, Fabricio R
Peñéñory, Alicia B
author_sort Heredia, Adrián A
collection PubMed
description A preparation of β-ketosulfides avoiding the use of thiols is described. The combination of a multicomponent reaction and a lipase-catalysed hydrolysis has been developed in order to obtain high chemical diversity employing a single sulfur donor. This methodology for the selective synthesis of a set of β-ketosulfides is performed under mild conditions and can be set up in one-pot two-step and on a gram-scale.
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spelling pubmed-64044162019-03-14 Thiol-free chemoenzymatic synthesis of β-ketosulfides Heredia, Adrián A López-Vidal, Martín G Kurina-Sanz, Marcela Bisogno, Fabricio R Peñéñory, Alicia B Beilstein J Org Chem Full Research Paper A preparation of β-ketosulfides avoiding the use of thiols is described. The combination of a multicomponent reaction and a lipase-catalysed hydrolysis has been developed in order to obtain high chemical diversity employing a single sulfur donor. This methodology for the selective synthesis of a set of β-ketosulfides is performed under mild conditions and can be set up in one-pot two-step and on a gram-scale. Beilstein-Institut 2019-02-11 /pmc/articles/PMC6404416/ /pubmed/30873224 http://dx.doi.org/10.3762/bjoc.15.34 Text en Copyright © 2019, Heredia et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Heredia, Adrián A
López-Vidal, Martín G
Kurina-Sanz, Marcela
Bisogno, Fabricio R
Peñéñory, Alicia B
Thiol-free chemoenzymatic synthesis of β-ketosulfides
title Thiol-free chemoenzymatic synthesis of β-ketosulfides
title_full Thiol-free chemoenzymatic synthesis of β-ketosulfides
title_fullStr Thiol-free chemoenzymatic synthesis of β-ketosulfides
title_full_unstemmed Thiol-free chemoenzymatic synthesis of β-ketosulfides
title_short Thiol-free chemoenzymatic synthesis of β-ketosulfides
title_sort thiol-free chemoenzymatic synthesis of β-ketosulfides
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404416/
https://www.ncbi.nlm.nih.gov/pubmed/30873224
http://dx.doi.org/10.3762/bjoc.15.34
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