Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp(2))–H activation and C(sp(3))–H amination

A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp(2))–H activation and C(sp(3))–H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffol...

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Detalles Bibliográficos
Autores principales: Song, Liangliang, Tian, Guilong, Van der Eycken, Johan, Van der Eycken, Erik V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404421/
https://www.ncbi.nlm.nih.gov/pubmed/30873242
http://dx.doi.org/10.3762/bjoc.15.52
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author Song, Liangliang
Tian, Guilong
Van der Eycken, Johan
Van der Eycken, Erik V
author_facet Song, Liangliang
Tian, Guilong
Van der Eycken, Johan
Van der Eycken, Erik V
author_sort Song, Liangliang
collection PubMed
description A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp(2))–H activation and C(sp(3))–H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance.
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spelling pubmed-64044212019-03-14 Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp(2))–H activation and C(sp(3))–H amination Song, Liangliang Tian, Guilong Van der Eycken, Johan Van der Eycken, Erik V Beilstein J Org Chem Letter A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp(2))–H activation and C(sp(3))–H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance. Beilstein-Institut 2019-02-27 /pmc/articles/PMC6404421/ /pubmed/30873242 http://dx.doi.org/10.3762/bjoc.15.52 Text en Copyright © 2019, Song et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Song, Liangliang
Tian, Guilong
Van der Eycken, Johan
Van der Eycken, Erik V
Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp(2))–H activation and C(sp(3))–H amination
title Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp(2))–H activation and C(sp(3))–H amination
title_full Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp(2))–H activation and C(sp(3))–H amination
title_fullStr Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp(2))–H activation and C(sp(3))–H amination
title_full_unstemmed Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp(2))–H activation and C(sp(3))–H amination
title_short Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp(2))–H activation and C(sp(3))–H amination
title_sort intramolecular cascade annulation triggered by rhodium(iii)-catalyzed sequential c(sp(2))–h activation and c(sp(3))–h amination
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404421/
https://www.ncbi.nlm.nih.gov/pubmed/30873242
http://dx.doi.org/10.3762/bjoc.15.52
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