Synthesis of the polyketide section of seragamide A and related cyclodepsipeptides via Negishi cross coupling

The synthesis of the polyketide section present in the potently cytotoxic marine cyclodepsipeptide jasplakinolide and related natural products, geodiamolides and seragamides, is reported. The key step is a Negishi cross coupling of (R)-(3-methoxy-2-methyl-3-oxopropyl)zinc(II) bromide and an (E)-iodo...

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Detalles Bibliográficos
Autores principales: Lang, Jan Hendrik, Lindel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404460/
https://www.ncbi.nlm.nih.gov/pubmed/30873243
http://dx.doi.org/10.3762/bjoc.15.53

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404460/
https://www.ncbi.nlm.nih.gov/pubmed/30873243
http://dx.doi.org/10.3762/bjoc.15.53

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