Distinctive single-channel properties of α4β2-nicotinic acetylcholine receptor isoforms

Central nervous system nicotinic acetylcholine receptors (nAChR) are predominantly of the α4β2 subtype. Two isoforms exist, with high or low agonist sensitivity (HS-(α4β2)(2)β2- and LS-(α4β2)(2)α4-nAChR). Both isoforms exhibit similar macroscopic potency and efficacy values at low acetylcholine (ACh...

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Detalles Bibliográficos
Autores principales: Weltzin, Maegan M., George, Andrew A., Lukas, Ronald J., Whiteaker, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405073/
https://www.ncbi.nlm.nih.gov/pubmed/30845161
http://dx.doi.org/10.1371/journal.pone.0213143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405073/
https://www.ncbi.nlm.nih.gov/pubmed/30845161
http://dx.doi.org/10.1371/journal.pone.0213143

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