Cargando…

Distinctive single-channel properties of α4β2-nicotinic acetylcholine receptor isoforms

Central nervous system nicotinic acetylcholine receptors (nAChR) are predominantly of the α4β2 subtype. Two isoforms exist, with high or low agonist sensitivity (HS-(α4β2)(2)β2- and LS-(α4β2)(2)α4-nAChR). Both isoforms exhibit similar macroscopic potency and efficacy values at low acetylcholine (ACh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weltzin, Maegan M., George, Andrew A., Lukas, Ronald J., Whiteaker, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405073/ https://www.ncbi.nlm.nih.gov/pubmed/30845161 http://dx.doi.org/10.1371/journal.pone.0213143

Ejemplares similares

Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of α4β2- nicotinic acetylcholine receptor intracellular structures
por: Weltzin, Maegan M., et al.
Publicado: (2021)

SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine receptors
por: O’Brien, Brittany C.V., et al.
Publicado: (2023)

Interactions between the rabies virus and nicotinic acetylcholine receptors: A potential role in rabies virus induced behavior modifications
por: Lian, Marianne, et al.
Publicado: (2022)

Distinctive Roles for α7*- and α9*-Nicotinic Acetylcholine Receptors in Inflammatory and Autoimmune Responses in the Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis
por: Liu, Qiang, et al.
Publicado: (2017)

Differential modulation of experimental autoimmune encephalomyelitis by α9*- and β2*-nicotinic acetylcholine receptors
por: Simard, Alain R., et al.
Publicado: (2013)

Single-channel properties of α3β4, α3β4α5 and α3β4β2 nicotinic acetylcholine receptors in mice lacking specific nicotinic acetylcholine receptor subunits
por: Ciuraszkiewicz, Anna, et al.
Publicado: (2013)

Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis
por: Liu, Qiang, et al.
Publicado: (2019)

Commentary: Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice
por: Morley, Barbara J., et al.
Publicado: (2018)

Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions()
por: Whiteaker, Paul, et al.
Publicado: (2023)

Cocaine potently blocks neuronal α(3)β(4) nicotinic acetylcholine receptors in SH-SY5Y cells
por: Ma, Ze-gang, et al.
Publicado: (2019)

Recent Developments in Novel Antidepressants Targeting α4β2-Nicotinic Acetylcholine Receptors: Miniperspective
por: Yu, Li-Fang, et al.
Publicado: (2014)

Mechanics of Channel Gating of the Nicotinic Acetylcholine Receptor
por: Liu, Xinli, et al.
Publicado: (2008)

Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse
por: Smith, Marci L., et al.
Publicado: (2014)

Somatic Integration of Single Ion Channel Responses of α7 Nicotinic Acetylcholine Receptors Enhanced by PNU-120596
por: Uteshev, Victor V.
Publicado: (2012)

α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties
por: Thomsen, Morten Skøtt, et al.
Publicado: (2015)

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine
por: Schapira, Matthieu, et al.
Publicado: (2002)

Simulations of Promising Indolizidine—α6-β2 Nicotinic Acetylcholine Receptor Complexes
por: Acquah, Francis A., et al.
Publicado: (2021)

Molecular Regulation of Betulinic Acid on α3β4 Nicotinic Acetylcholine Receptors
por: Lee, Shinhui, et al.
Publicado: (2021)

Availability of Central α4β2* Nicotinic Acetylcholine Receptors in Human Obesity
por: Schweickert de Palma, Eva, et al.
Publicado: (2022)

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor
por: Abraham, Nikita, et al.
Publicado: (2017)

The α5 Nicotinic Acetylcholine Receptor Subunit Differentially Modulates α4β2(*) and α3β4(*) Receptors
por: Scholze, Petra, et al.
Publicado: (2020)

Distinct Evolutionary Trajectories of Neuronal and Hair Cell Nicotinic Acetylcholine Receptors
por: Marcovich, Irina, et al.
Publicado: (2020)

Menthol Binding and Inhibition of α7-Nicotinic Acetylcholine Receptors
por: Ashoor, Abrar, et al.
Publicado: (2013)

Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor
por: Natarajan, Kathiresan, et al.
Publicado: (2020)

Role of the α7 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis
por: Vieira-Alves, Ildernandes, et al.
Publicado: (2020)

Peptide Inhibitors of the α-Cobratoxin–Nicotinic Acetylcholine Receptor Interaction
por: Lynagh, Timothy, et al.
Publicado: (2020)

Targeting α7 nicotinic acetylcholine receptors for chronic pain
por: Zhou, Ya-Qun, et al.
Publicado: (2022)

Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor
por: Ma, Yuan, et al.
Publicado: (2022)

Monkey Adrenal Chromaffin Cells Express α6β4* Nicotinic Acetylcholine Receptors
por: Hernández-Vivanco, Alicia, et al.
Publicado: (2014)

Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer’s dementia
por: Sabri, Osama, et al.
Publicado: (2018)

Molecular Regulation of α3β4 Nicotinic Acetylcholine Receptors by Lupeol in Cardiovascular System
por: Eom, Sanung, et al.
Publicado: (2020)

Stoichiometry-Selective Antagonism of α4β2 Nicotinic Acetylcholine Receptors by Fluoroquinolone Antibiotics
por: Sanders, Victoria R., et al.
Publicado: (2022)

Bibliometric analysis of nicotinic acetylcholine receptors channel research (2000-2020)
por: Zhu, Xueping, et al.
Publicado: (2021)

Human α4β2 Nicotinic Acetylcholine Receptor as a Novel Target of Oligomeric α-Synuclein
por: Liu, Qiang, et al.
Publicado: (2013)

Nicotinic acetylcholine receptors and cancer
por: DANG, NINGNING, et al.
Publicado: (2016)

Structurally Similar Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects
por: Gill-Thind, JasKiran K., et al.
Publicado: (2015)

Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids
por: Alijevic, Omar, et al.
Publicado: (2022)

Acetylcholine receptor in planar lipid bilayers. Characterization of the channel properties of the purified nicotinic acetylcholine receptor from Torpedo californica reconstituted in planar lipid bilayers
Publicado: (1984)

Expression of the α7 nicotinic acetylcholine receptor in human lung cells
por: Plummer, Howard K, et al.
Publicado: (2005)

Modulation of dopamine release by α7-type nicotinic acetylcholine receptors
por: Maex, Reinoud, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_gm5cbk0s7jptropd84qo45cs2t