Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer

Complement-mediated cytotoxicity may act as a selective pressure for tumor overexpression of complement regulators. We hypothesize that the same selective pressure could lead to complement alterations at the genetic level. We find that, when analyzed as a pathway, mutations in complement genes occur...

Descripción completa

Detalles Bibliográficos
Autores principales: Olcina, Monica M., Balanis, Nikolas G., Kim, Ryan K., Aksoy, B. Arman, Kodysh, Julia, Thompson, Michael J., Hammerbacher, Jeff, Graeber, Thomas G., Giaccia, Amato J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405289/
https://www.ncbi.nlm.nih.gov/pubmed/30590044
http://dx.doi.org/10.1016/j.celrep.2018.11.093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405289/
https://www.ncbi.nlm.nih.gov/pubmed/30590044
http://dx.doi.org/10.1016/j.celrep.2018.11.093

Ejemplares similares