Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

Cholesterol is essential for cells to grow and proliferate. While normal mammalian cells meet their need for cholesterol through its uptake or de novo synthesis(1), the extent to which cancer cells rely on each of these pathways remains poorly understood. Here, using a competitive proliferation assa...

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Detalles Bibliográficos
Autores principales: Garcia-Bermudez, Javier, Baudrier, Lou, Can Bayraktar, Erol, Shen, Yihui, La, Konnor, Guarecuco, Rohiverth, Yucel, Burcu, Fiore, Danilo, Tavora, Bernardo, Freinkman, Elizaveta, Ham Chan, Sze, Lewis, Caroline, Min, Wei, Inghirami, Giorgio, Sabatini, David M, Birsoy, Kıvanç
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405297/
https://www.ncbi.nlm.nih.gov/pubmed/30760928
http://dx.doi.org/10.1038/s41586-019-0945-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405297/
https://www.ncbi.nlm.nih.gov/pubmed/30760928
http://dx.doi.org/10.1038/s41586-019-0945-5

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