Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice

Atherosclerosis is a progressive inflammatory vascular disorder, complicated by plaque rupture and subsequently atherothrombosis. In vitro studies indicate that key clotting proteases, such as factor Xa (FXa), can promote atherosclerosis, presumably mediated through protease activated receptors (PAR...

Descripción completa

Detalles Bibliográficos
Autores principales: Posthuma, Jelle J., Posma, Jens J. N., van Oerle, Rene, Leenders, Peter, van Gorp, Rick H., Jaminon, Armand M. G., Mackman, Nigel, Heitmeier, Stefan, Schurgers, Leon J., ten Cate, Hugo, Spronk, Henri M. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405752/
https://www.ncbi.nlm.nih.gov/pubmed/30846818
http://dx.doi.org/10.1038/s41598-019-40602-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405752/
https://www.ncbi.nlm.nih.gov/pubmed/30846818
http://dx.doi.org/10.1038/s41598-019-40602-w

Ejemplares similares