Identification of a novel scaffold for a small molecule GPR139 receptor agonist

GPR139 is an orphan G protein-coupled receptor (GPCR) that is primarily expressed in the brain in regions known to regulate motor control and metabolism. Here, we screened a diverse 4,000 compound library in order to identify GPR139 agonists. We identified 11 initial hits in a calcium mobilization s...

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Detalles Bibliográficos
Autores principales: Nøhr, Anne Cathrine, Shehata, Mohamed A., Palmer, Daniel, Pokhrel, Rina, Vallianou, Maria, Foster, Simon R., Gentry, Patrick R., Gloriam, David E., Bräuner-Osborne, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405842/
https://www.ncbi.nlm.nih.gov/pubmed/30846711
http://dx.doi.org/10.1038/s41598-019-40085-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405842/
https://www.ncbi.nlm.nih.gov/pubmed/30846711
http://dx.doi.org/10.1038/s41598-019-40085-9

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