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Reactive centre loop dynamics and serpin specificity

Serine proteinase inhibitors (serpins), typically fold to a metastable native state and undergo a major conformational change in order to inhibit target proteases. However, conformational lability of the native serpin fold renders them susceptible to misfolding and aggregation, and underlies misfold...

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Detalles Bibliográficos
Autores principales: Marijanovic, Emilia M., Fodor, James, Riley, Blake T., Porebski, Benjamin T., Costa, Mauricio G. S., Kass, Itamar, Hoke, David E., McGowan, Sheena, Buckle, Ashley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405850/
https://www.ncbi.nlm.nih.gov/pubmed/30846766
http://dx.doi.org/10.1038/s41598-019-40432-w