Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport

Dysregulation of dopaminergic system induced by HIV-1 Tat protein-mediated direct inhibition of the dopamine transporter (DAT) has been implicated as a mediating factor of HIV-1 associated neurocognitive disorders. We have reported that single point mutations on human DAT (hDAT) at tyrosine88 (Y88F)...

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Detalles Bibliográficos
Autores principales: Sun, Wei-Lun, Quizon, Pamela M., Yuan, Yaxia, Strauss, Matthew J., McCain, Richard, Zhan, Chang-Guo, Zhu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405875/
https://www.ncbi.nlm.nih.gov/pubmed/30846720
http://dx.doi.org/10.1038/s41598-019-39872-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405875/
https://www.ncbi.nlm.nih.gov/pubmed/30846720
http://dx.doi.org/10.1038/s41598-019-39872-1

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