p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury

p38α MAPK negatively regulates the G(1)/S and G(2)/M cell cycle transitions. However, liver-specific p38α deficiency impairs cytokinesis and reduces hepatocyte proliferation during cirrhosis and aging in mice. In this work, we have studied how p38α down-regulation affects hepatocyte proliferation af...

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Detalles Bibliográficos
Autores principales: Rius-Pérez, Sergio, Tormos, Ana M., Pérez, Salvador, Finamor, Isabela, Rada, Patricia, Valverde, Ángela M., Nebreda, Angel R., Sastre, Juan, Taléns-Visconti, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405944/
https://www.ncbi.nlm.nih.gov/pubmed/30846722
http://dx.doi.org/10.1038/s41598-019-39428-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405944/
https://www.ncbi.nlm.nih.gov/pubmed/30846722
http://dx.doi.org/10.1038/s41598-019-39428-3

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