Tankyrase (PARP5) Inhibition Induces Bone Loss through Accumulation of Its Substrate SH3BP2

There is considerable interest in tankyrase because of its potential use in cancer therapy. Tankyrase catalyzes the ADP-ribosylation of a variety of target proteins and regulates various cellular processes. The anti-cancer effects of tankyrase inhibitors are mainly due to their suppression of Wnt si...

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Detalles Bibliográficos
Autores principales: Mukai, Tomoyuki, Fujita, Shunichi, Morita, Yoshitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406327/
https://www.ncbi.nlm.nih.gov/pubmed/30813388
http://dx.doi.org/10.3390/cells8020195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406327/
https://www.ncbi.nlm.nih.gov/pubmed/30813388
http://dx.doi.org/10.3390/cells8020195

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