Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I

The role of mitochondrial GSH (mGSH) in the enhanced age-related susceptibility to xenobiotic toxicity is not well defined. We determined mGSH status and indices of mitochondrial bioenergetics in hepatocytes from young and old F344 rats treated with 300 μM menadione, a concentration that causes 50%...

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Detalles Bibliográficos
Autores principales: Thomas, Nicholas O., Shay, Kate P., Hagen, Tory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406584/
https://www.ncbi.nlm.nih.gov/pubmed/30851669
http://dx.doi.org/10.1016/j.redox.2019.101155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406584/
https://www.ncbi.nlm.nih.gov/pubmed/30851669
http://dx.doi.org/10.1016/j.redox.2019.101155

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