Cargando…

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

Lipid droplets (LDs) serve as energy rich reservoirs and have been associated with apolipoprotein E (APOE) and neurodegeneration. The E4 allele of APOE (E4) is the strongest genetic risk factor for the development of late onset Alzheimer’s disease (AD). Since both E4 carriers and individuals with AD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farmer, Brandon C., Kluemper, Jude, Johnson, Lance A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406677/ https://www.ncbi.nlm.nih.gov/pubmed/30791549 http://dx.doi.org/10.3390/cells8020182

Ejemplares similares

Lipid Droplets in Neurodegenerative Disorders
por: Farmer, Brandon C., et al.
Publicado: (2020)

Polyunsaturated fatty acids alter the formation of lipid droplets and eicosanoid production in Leishmania promastigotes
por: Andrade, Yasmin Monara Ferreira de Sousa, et al.
Publicado: (2023)

Astrocytes in stress accumulate lipid droplets
por: Smolič, Tina, et al.
Publicado: (2021)

Hyperglycemia Alters Astrocyte Metabolism and Inhibits Astrocyte Proliferation
por: Li, Wenjun, et al.
Publicado: (2018)

Lipid Droplet-Organelle Contact Sites as Hubs for Fatty Acid Metabolism, Trafficking, and Metabolic Channeling
por: Renne, Mike F., et al.
Publicado: (2021)

Decreased PEDF Promotes Hepatic Fatty Acid Uptake and Lipid Droplet Formation in the Pathogenesis of NAFLD
por: Huang, Kuang-Tzu, et al.
Publicado: (2020)

Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome
por: Johnson, Lance A., et al.
Publicado: (2017)

Guanosine effect on cholesterol efflux and apolipoprotein E expression in astrocytes
por: Ballerini, Patrizia, et al.
Publicado: (2006)

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes
por: Fan, Jianjia, et al.
Publicado: (2016)

Nitrogen Deprivation Induces Lipid Droplet Accumulation and Alters Fatty Acid Metabolism in Symbiotic Dinoflagellates Isolated from Aiptasia pulchella
por: Weng, Li-Chi, et al.
Publicado: (2014)

Fatty Acid Binding Protein 3 (FABP3) and Apolipoprotein E4 (ApoE4) as Lipid Metabolism-Related Biomarkers of Alzheimer’s Disease
por: Dulewicz, Maciej, et al.
Publicado: (2021)

Cholesterol-induced robust Ca oscillation in astrocytes required for survival and lipid droplet formation in high-cholesterol condition
por: Adachi, Chihiro, et al.
Publicado: (2022)

Classical Activation of Macrophages Leads to Lipid Droplet Formation Without de novo Fatty Acid Synthesis
por: Rosas-Ballina, Mauricio, et al.
Publicado: (2020)

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism
por: Qi, Guoyuan, et al.
Publicado: (2021)

Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota
por: Yun, Kyung Eun, et al.
Publicado: (2020)

Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability
por: Konings, Sabine C., et al.
Publicado: (2021)

Changing the phospholipid composition of lipid droplets alters localization of select lipid droplet proteins
por: Renier, Timothy J., et al.
Publicado: (2023)

Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages
por: Wu, Hao, et al.
Publicado: (2019)

A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets
por: Fei, Weihua, et al.
Publicado: (2011)

Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline
por: González-Domínguez, Raúl, et al.
Publicado: (2022)

Lipid droplets and polyunsaturated fatty acid trafficking: Balancing life and death
por: Danielli, Mauro, et al.
Publicado: (2023)

Lipid droplet dynamics in alcoholic fatty liver disease
por: Schulze, Ryan J., et al.
Publicado: (2019)

Fatty acid induced lipolysis influences embryo development, gene expression and lipid droplet formation in the porcine cumulus cells
por: Pawlak, Piotr, et al.
Publicado: (2020)

Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells
por: Lettiero, Barbara, et al.
Publicado: (2018)

Spastin Binds to Lipid Droplets and Affects Lipid Metabolism
por: Papadopoulos, Chrisovalantis, et al.
Publicado: (2015)

Characterization of Lipid and Lipid Droplet Metabolism in Human HCC
por: Berndt, Nikolaus, et al.
Publicado: (2019)

Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins
por: Morales, Pablo Esteban, et al.
Publicado: (2017)

Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells
por: Colas, Kilian, et al.
Publicado: (2021)

HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets
por: Shah, Tariq, et al.
Publicado: (2015)

The Roles of Fatty Acids and Apolipoproteins in the Kidneys
por: Pan, Xiaoyue
Publicado: (2022)

Effects of Fatty-Type and Lean-Type on Growth Performance and Lipid Droplet Metabolism in Pekin Ducks
por: Zhuang, Zhong, et al.
Publicado: (2022)

Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice
por: Maezawa, Izumi, et al.
Publicado: (2006)

Raman Study on Lipid Droplets in Hepatic Cells Co-Cultured with Fatty Acids
por: Paramitha, Pradjna N., et al.
Publicado: (2021)

Polyunsaturated fatty acids promote the rapid fusion of lipid droplets in Caenorhabditis elegans
por: Wang, Yanli, et al.
Publicado: (2022)

Erratum: Lipid droplets and polyunsaturated fatty acid trafficking: Balancing life and death
por: Frontiers Production Office,
Publicado: (2023)

The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells
por: Plötz, Thomas, et al.
Publicado: (2016)

Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers
por: Perkins, Michelle, et al.
Publicado: (2016)

Formation and characterization of lipid droplets of the bovine corpus luteum
por: Talbott, Heather A., et al.
Publicado: (2020)

Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes
por: Zheng, Xiaofeng, et al.
Publicado: (2022)

Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling
por: Yin, Jun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9jj0vrk4fap5gdic8gta3lhuua