A Personalized CYP2C19 Phenotype-Guided Dosing Regimen of Voriconazole Using a Population Pharmacokinetic Analysis

Highly variable and non-linear pharmacokinetics of voriconazole are mainly caused by CYP2C19 polymorphisms. This study aimed to develop a mechanistic population pharmacokinetic model including the CYP2C19 phenotype, and to assess the appropriateness of various dosing regimens based on the therapeuti...

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Detalles Bibliográficos
Autores principales: Kim, Yun, Rhee, Su-jin, Park, Wan Beom, Yu, Kyung-Sang, Jang, In-Jin, Lee, SeungHwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406770/
https://www.ncbi.nlm.nih.gov/pubmed/30744151
http://dx.doi.org/10.3390/jcm8020227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406770/
https://www.ncbi.nlm.nih.gov/pubmed/30744151
http://dx.doi.org/10.3390/jcm8020227

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