In Silico Study Probes Potential Inhibitors of Human Dihydrofolate Reductase for Cancer Therapeutics

Dihydrofolate reductase (DHFR) is an essential cellular enzyme and thereby catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). In cancer medication, inhibition of human DHFR (hDHFR) remains a promising strategy, as it depletes THF and slows DNA synthesis and cell proliferation. In th...

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Detalles Bibliográficos
Autores principales: Rana, Rabia Mukhtar, Rampogu, Shailima, Zeb, Amir, Son, Minky, Park, Chanin, Lee, Gihwan, Yoon, Sanghwa, Baek, Ayoung, Parameswaran, Sarvanan, Park, Seok Ju, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406960/
https://www.ncbi.nlm.nih.gov/pubmed/30754680
http://dx.doi.org/10.3390/jcm8020233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406960/
https://www.ncbi.nlm.nih.gov/pubmed/30754680
http://dx.doi.org/10.3390/jcm8020233

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