Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability

Paclitaxel is a frontline drug for the treatment of epithelial ovarian cancer (EOC). However, following paclitaxel-platinum based chemotherapy, tumor recurrence occurs in most ovarian cancer patients. Chromosomal instability (CIN) is a hallmark of cancer and represents genetic variation fueling tumo...

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Detalles Bibliográficos
Autores principales: Raab, Monika, Sanhaji, Mourad, Zhou, Shengtao, Rödel, Franz, El-Balat, Ahmed, Becker, Sven, Strebhardt, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407080/
https://www.ncbi.nlm.nih.gov/pubmed/30851646
http://dx.doi.org/10.1016/j.neo.2019.01.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407080/
https://www.ncbi.nlm.nih.gov/pubmed/30851646
http://dx.doi.org/10.1016/j.neo.2019.01.007

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