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Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability

Paclitaxel is a frontline drug for the treatment of epithelial ovarian cancer (EOC). However, following paclitaxel-platinum based chemotherapy, tumor recurrence occurs in most ovarian cancer patients. Chromosomal instability (CIN) is a hallmark of cancer and represents genetic variation fueling tumo...

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Detalles Bibliográficos
Autores principales:	Raab, Monika, Sanhaji, Mourad, Zhou, Shengtao, Rödel, Franz, El-Balat, Ahmed, Becker, Sven, Strebhardt, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2019
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407080/ https://www.ncbi.nlm.nih.gov/pubmed/30851646 http://dx.doi.org/10.1016/j.neo.2019.01.007

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