Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch

Hedgehog signalling (Hh) is a developmental conserved pathway strongly involved in cancers when deregulated. This important pathway is orchestrated by numerous regulators, transduces through distinct routes and is finely tuned at multiple levels. In this regard, ubiquitylation processes stand as ess...

Descripción completa

Detalles Bibliográficos
Autores principales: Infante, Paola, Lospinoso Severini, Ludovica, Bernardi, Flavia, Bufalieri, Francesca, Di Marcotullio, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407099/
https://www.ncbi.nlm.nih.gov/pubmed/30699938
http://dx.doi.org/10.3390/cells8020098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407099/
https://www.ncbi.nlm.nih.gov/pubmed/30699938
http://dx.doi.org/10.3390/cells8020098

Ejemplares similares