Temple syndrome in a patient with variably methylated CpGs at the primary MEG3/DLK1:IG-DMR and severely hypomethylated CpGs at the secondary MEG3:TSS-DMR

BACKGROUND: The human chromosome 14q32.2 imprinted region harbors the primary MEG3/DLK1:IG-differentially methylated region (DMR) and secondary MEG3:TSS-DMR. The MEG3:TSS-DMR can remain unmethylated only in the presence of unmethylated MEG3/DLK1:IG-DMR in somatic tissues, but not in the placenta, be...

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Detalles Bibliográficos
Autores principales: Kagami, Masayo, Yanagisawa, Atsuhiro, Ota, Miyuki, Matsuoka, Kentaro, Nakamura, Akie, Matsubara, Keiko, Nakabayashi, Kazuhiko, Takada, Shuji, Fukami, Maki, Ogata, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407230/
https://www.ncbi.nlm.nih.gov/pubmed/30846001
http://dx.doi.org/10.1186/s13148-019-0640-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407230/
https://www.ncbi.nlm.nih.gov/pubmed/30846001
http://dx.doi.org/10.1186/s13148-019-0640-2

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