Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells

PTEN is a tumor suppressor that is highly mutated in a variety of human cancers. Recent studies have suggested a link between PTEN loss and deficiency in the non-homologous end-joining (NHEJ) pathway of DNA double strand break (DSB) repair. As a means to achieve synthetic lethality in this context,...

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Detalles Bibliográficos
Autores principales: Turchick, Audrey, Liu, Yanfeng, Zhao, Weixi, Cohen, Inessa, Glazer, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407680/
https://www.ncbi.nlm.nih.gov/pubmed/30863489
http://dx.doi.org/10.18632/oncotarget.26654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407680/
https://www.ncbi.nlm.nih.gov/pubmed/30863489
http://dx.doi.org/10.18632/oncotarget.26654

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