Identification of β-carboline and canthinone alkaloids as anti-inflammatory agents but with different inhibitory profile on the expression of iNOS and COX-2 in lipopolysaccharide-activated RAW 264.7 macrophages

A compound library, which consists of 75 natural β-carboline-type or canthinone-type alkaloids from Simaroubaceae plants and their chemical synthetic analogues, was screened for the anti-inflammatory activity by inhibition of the overproduction of inflammatory mediator nitric oxide (NO) in lipopolys...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Pan, Li, Huixiang, Luan, Ruiling, Huang, Guiyan, Liu, Yanan, Wang, Mengdi, Chao, Qiuli, Wang, Liying, Li, Danna, Fan, Huaying, Chen, Daquan, Li, Linyu, Matsuzaki, Keiichi, Li, Wei, Koike, Kazuo, Zhao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407838/
https://www.ncbi.nlm.nih.gov/pubmed/30324332
http://dx.doi.org/10.1007/s11418-018-1251-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407838/
https://www.ncbi.nlm.nih.gov/pubmed/30324332
http://dx.doi.org/10.1007/s11418-018-1251-5

Ejemplares similares