PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here, we investigated the physiologic function of the conserved lncRNA Norad in vivo. Deletion of Norad in mice results in genomic instability and mitochond...

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Detalles Bibliográficos
Autores principales: Kopp, Florian, Elguindy, Mahmoud M, Yalvac, Mehmet E, Zhang, He, Chen, Beibei, Gillett, Frank A, Lee, Sungyul, Sivakumar, Sushama, Yu, Hongtao, Xie, Yang, Mishra, Prashant, Sahenk, Zarife, Mendell, Joshua T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407921/
https://www.ncbi.nlm.nih.gov/pubmed/30735131
http://dx.doi.org/10.7554/eLife.42650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407921/
https://www.ncbi.nlm.nih.gov/pubmed/30735131
http://dx.doi.org/10.7554/eLife.42650

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