Cargando…

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here, we investigated the physiologic function of the conserved lncRNA Norad in vivo. Deletion of Norad in mice results in genomic instability and mitochond...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kopp, Florian, Elguindy, Mahmoud M, Yalvac, Mehmet E, Zhang, He, Chen, Beibei, Gillett, Frank A, Lee, Sungyul, Sivakumar, Sushama, Yu, Hongtao, Xie, Yang, Mishra, Prashant, Sahenk, Zarife, Mendell, Joshua T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407921/ https://www.ncbi.nlm.nih.gov/pubmed/30735131 http://dx.doi.org/10.7554/eLife.42650

Ejemplares similares

PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD
por: Elguindy, Mahmoud M, et al.
Publicado: (2019)

Aging well with Norad
por: Marques, Filipa Carvalhal, et al.
Publicado: (2019)

Widespread premature transcription termination of Arabidopsis thaliana NLR genes by the spen protein FPA
por: Parker, Matthew T, et al.
Publicado: (2021)

Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants
por: Serdar, Lucas D, et al.
Publicado: (2020)

When 19 is greater than 92
por: Zeitels, Lauren R, et al.
Publicado: (2013)

MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion
por: Zheng, Ge, et al.
Publicado: (2018)

Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer
por: Ni, Thomas K, et al.
Publicado: (2016)

A DCL3 dicing code within Pol IV-RDR2 transcripts diversifies the siRNA pool guiding RNA-directed DNA methylation
por: Loffer, Andrew, et al.
Publicado: (2022)

SAM68 is required for regulation of Pumilio by the NORAD long noncoding RNA
por: Tichon, Ailone, et al.
Publicado: (2018)

Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres
por: Guin, Krishnendu, et al.
Publicado: (2020)

The Potential of NORAD–PUMILIO–RALGAPB Regulatory Axis as a Biomarker in Breast Cancer
por: Muller, Cristiane Sato Mara, et al.
Publicado: (2022)

Proteins pinpoint double strand breaks
por: Cox, Michael M
Publicado: (2013)

The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress
por: Wakida, Takeshi, et al.
Publicado: (2017)

Conserved noncoding transcription and core promoter regulatory code in early Drosophila development
por: Batut, Philippe J, et al.
Publicado: (2017)

Telomere repeats induce domains of H3K27 methylation in Neurospora
por: Jamieson, Kirsty, et al.
Publicado: (2018)

Cis-regulatory evolution integrated the Bric-à-brac transcription factors into a novel fruit fly gene regulatory network
por: Roeske, Maxwell J, et al.
Publicado: (2018)

The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology
por: Fu, Yu, et al.
Publicado: (2018)

High levels of histones promote whole-genome-duplications and trigger a Swe1(WEE1)-dependent phosphorylation of Cdc28(CDK1)
por: Maya Miles, Douglas, et al.
Publicado: (2018)

NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins
por: Campbell, Amy E, et al.
Publicado: (2018)

Codon choice directs constitutive mRNA levels in trypanosomes
por: de Freitas Nascimento, Janaina, et al.
Publicado: (2018)

Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice
por: Gregorova, Sona, et al.
Publicado: (2018)

A gene-specific T2A-GAL4 library for Drosophila
por: Lee, Pei-Tseng, et al.
Publicado: (2018)

CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape
por: Howe, Françoise S, et al.
Publicado: (2017)

A quantitative hypermorphic CNGC allele confers ectopic calcium flux and impairs cellular development
por: Chiasson, David M, et al.
Publicado: (2017)

Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria
por: Quin, Jaclyn E, et al.
Publicado: (2017)

Transcription of a 5’ extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter
por: Chia, Minghao, et al.
Publicado: (2017)

Kinetochore inactivation by expression of a repressive mRNA
por: Chen, Jingxun, et al.
Publicado: (2017)

RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit
por: Milligan, Laura, et al.
Publicado: (2017)

Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription
por: Zhou, Zhen, et al.
Publicado: (2017)

Rapid DNA replication origin licensing protects stem cell pluripotency
por: Matson, Jacob Peter, et al.
Publicado: (2017)

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
por: Altemose, Nicolas, et al.
Publicado: (2017)

Efficient termination of nuclear lncRNA transcription promotes mitochondrial genome maintenance
por: du Mee, Dorine Jeanne Mariëtte, et al.
Publicado: (2018)

YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci
por: Shichino, Yuichi, et al.
Publicado: (2018)

Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis
por: Phizicky, David V, et al.
Publicado: (2018)

Genome-wide mapping of sister chromatid exchange events in single yeast cells using Strand-seq
por: Claussin, Clémence, et al.
Publicado: (2017)

Convergence of topological domain boundaries, insulators, and polytene interbands revealed by high-resolution mapping of chromatin contacts in the early Drosophila melanogaster embryo
por: Stadler, Michael R, et al.
Publicado: (2017)

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
por: Povedano, Juan Manuel, et al.
Publicado: (2018)

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss
por: Espino Guarch, Meritxell, et al.
Publicado: (2018)

Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages
por: Sacta, Maria A, et al.
Publicado: (2018)

p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways
por: Roy, Sunetra, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_tk9q0045vn2jq0t2it3iqhdhqi