HLA class II antibodies induce necrotic cell death in human endothelial cells via a lysosomal membrane permeabilization-mediated pathway

Antibody-mediated rejection (AMR) is the major cause of allograft loss after solid organ transplantation. Circulating donor-specific antibodies against human leukocyte antigen (HLA), in particular HLA class II antibodies are critical for the pathogenesis of AMR via interactions with endothelial cell...

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Detalles Bibliográficos
Autores principales: Aljabri, Abid, Vijayan, Vijith, Stankov, Metodi, Nikolin, Christoph, Figueiredo, Constanca, Blasczyk, Rainer, Becker, Jan Ulrich, Linkermann, Andreas, Immenschuh, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408495/
https://www.ncbi.nlm.nih.gov/pubmed/30850581
http://dx.doi.org/10.1038/s41419-019-1319-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408495/
https://www.ncbi.nlm.nih.gov/pubmed/30850581
http://dx.doi.org/10.1038/s41419-019-1319-5

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