A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death

The Warburg effect, wherein cancer cells prefer glycolysis rather than oxidative phosphorylation even under normoxic conditions, is a major characteristic of malignant tumors. Lactate dehydrogenase A (LDHA) is the main enzyme regulating the Warburg effect, and is thus, a major target for novel anti-...

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Detalles Bibliográficos
Autores principales: Kim, Eun-Yeong, Chung, Tae-Wook, Han, Chang Woo, Park, So Young, Park, Kang Hyun, Jang, Se Bok, Ha, Ki-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408513/
https://www.ncbi.nlm.nih.gov/pubmed/30850682
http://dx.doi.org/10.1038/s41598-019-40617-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408513/
https://www.ncbi.nlm.nih.gov/pubmed/30850682
http://dx.doi.org/10.1038/s41598-019-40617-3

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