Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase

UDP-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (LpxA) catalyzes the first step of lipid A biosynthesis, the transfer of an R-3-hydroxyacyl chain from its acyl carrier protein (ACP) to the 3-OH group of UDP-GlcNAc. Essential in the growth of Gram-negative bacteria, LpxA is a logical target for...

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Detalles Bibliográficos
Autores principales: Dangkulwanich, Manchuta, Raetz, Christian R. H., Williams, Allison H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408518/
https://www.ncbi.nlm.nih.gov/pubmed/30850651
http://dx.doi.org/10.1038/s41598-019-40418-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408518/
https://www.ncbi.nlm.nih.gov/pubmed/30850651
http://dx.doi.org/10.1038/s41598-019-40418-8

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