Development of an efficient cytosolic isobutanol production pathway in Saccharomyces cerevisiae by optimizing copy numbers and expression of the pathway genes based on the toxic effect of α-acetolactate

Isobutanol production in Saccharomyces cerevisiae is limited by subcellular compartmentalization of the pathway enzymes. In this study, we improved isobutanol production in S. cerevisiae by constructing an artificial cytosolic isobutanol biosynthetic pathway consisting of AlsS, α-acetolactate syntha...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Seong-Hee, Hahn, Ji-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408573/
https://www.ncbi.nlm.nih.gov/pubmed/30850698
http://dx.doi.org/10.1038/s41598-019-40631-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408573/
https://www.ncbi.nlm.nih.gov/pubmed/30850698
http://dx.doi.org/10.1038/s41598-019-40631-5

Ejemplares similares