Increased NHE1 expression is targeted by specific inhibitor cariporide to sensitize resistant breast cancer cells to doxorubicin in vitro and in vivo

BACKGROUND: The Na(+)/H(+) exchanger (NHE1) plays a crucial role in cancer cell proliferation and metastasis. However, the mechanism underlying chemotherapeutic resistance in cancer cells has not been completely elucidated. The NHE1 inhibitor cariporide has been demonstrated to inhibit human cancer...

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Detalles Bibliográficos
Autores principales: Chen, Qi, Liu, Yueqin, Zhu, Xiao-lan, Feng, Fan, Yang, Hui, Xu, Wenlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408845/
https://www.ncbi.nlm.nih.gov/pubmed/30849956
http://dx.doi.org/10.1186/s12885-019-5397-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408845/
https://www.ncbi.nlm.nih.gov/pubmed/30849956
http://dx.doi.org/10.1186/s12885-019-5397-7

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