Cargando…

Metabolic Regulators Nampt and Sirt6 Serially Participate in the Macrophage Interferon Antiviral Cascade

Molecular determinants underlying interferon (IFN)-macrophage biology can help delineate enzyme systems, pathways and mechanisms for enabling host-directed therapeutic approaches against infection. Notably, while the IFN antiviral response is known to be directly coupled to mevalonate-sterol biosynt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dantoft, Widad, Robertson, Kevin A., Watkins, W. John, Strobl, Birgit, Ghazal, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409323/ https://www.ncbi.nlm.nih.gov/pubmed/30886604 http://dx.doi.org/10.3389/fmicb.2019.00355

Ejemplares similares

Evolutionary Origin of the Interferon–Immune Metabolic Axis: The Sterol–Vitamin D Link
por: Newmark, Harry, et al.
Publicado: (2017)

Multifaceted Antiviral Actions of Interferon-stimulated Gene Products
por: Strobl, Birgit, et al.
Publicado: (2012)

The regulation of antiviral activity of interferon epsilon
por: Zhao, Fu-Rong, et al.
Publicado: (2022)

Resveratrol Differentially Regulates NAMPT and SIRT1 in Hepatocarcinoma Cells and Primary Human Hepatocytes
por: Schuster, Susanne, et al.
Publicado: (2014)

Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes
por: Schuster, Susanne, et al.
Publicado: (2014)

Functional Involvement of Interferon-Inducible Transmembrane Proteins in Antiviral Immunity
por: Liao, Yuan, et al.
Publicado: (2019)

Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity
por: Lynn, Heather, et al.
Publicado: (2023)

The Interferon-inducible NAMPT acts as a protein phosphoribosylase to restrict viral infection
por: Zhang, Shu, et al.
Publicado: (2023)

Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis
por: Guo, Jia Yi, et al.
Publicado: (2017)

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response
por: Blanc, Mathieu, et al.
Publicado: (2013)

Expression and Regulation of Nampt in Human Islets
por: Kover, Karen, et al.
Publicado: (2013)

Long Non-coding RNAs: Regulators of Viral Infection and the Interferon Antiviral Response
por: Qiu, Lipeng, et al.
Publicado: (2018)

Replicative Senescence in Human Fibroblasts Is Delayed by Hydrogen Sulfide in a NAMPT/SIRT1 Dependent Manner
por: Sanokawa-Akakura, Reiko, et al.
Publicado: (2016)

NAMPT-Mediated Salvage Synthesis of NAD(+) Controls Morphofunctional Changes of Macrophages
por: Venter, Gerda, et al.
Publicado: (2014)

Antiviral effects of interferon-stimulated genes in bats
por: Zhang, Dan, et al.
Publicado: (2023)

Regulation of macrophage growth and antiviral activity by interferon- gamma
Publicado: (1989)

The role of SIRT1 in the process of Toxoplasma gondii infection of RAW 264.7 macrophages
por: Dong, Kai, et al.
Publicado: (2022)

Modulation of Macrophage Polarization by Viruses: Turning Off/On Host Antiviral Responses
por: Yu, Shaoxiong, et al.
Publicado: (2022)

Enterovirus 71 Antagonizes Antiviral Effects of Type III Interferon and Evades the Clearance of Intestinal Intraepithelial Lymphocytes
por: Dong, Yuanmin, et al.
Publicado: (2022)

Interferon Lambda Signaling in Macrophages Is Necessary for the Antiviral Response to Influenza
por: Mallampalli, Rama K., et al.
Publicado: (2021)

Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1
por: Ma, Cao, et al.
Publicado: (2017)

Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis()
por: Brandl, Lydia, et al.
Publicado: (2019)

NAMPT/SIRT1 Attenuate Ang II-Induced Vascular Remodeling and Vulnerability to Hypertension by Inhibiting the ROS/MAPK Pathway
por: Zhou, Lei, et al.
Publicado: (2020)

miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD(+)/SIRT inactivation
por: Gong, Hui, et al.
Publicado: (2022)

Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory-fibrosis through the NF-κB p65 and Sirt1 pathway; NMN alleviates diabetic nephropathy inflammatory-fibrosis by inhibiting endogenous Nampt
por: Chen, Ye, et al.
Publicado: (2017)

Interferon Gamma-Inducible NAMPT in Melanoma Cells Serves as a Mechanism of Resistance to Enhance Tumor Growth
por: Barba, Cindy, et al.
Publicado: (2023)

Antiviral Activity of Interferon Alpha-Inducible Protein 27 Against Hepatitis B Virus Gene Expression and Replication
por: Ullah, Hafiz, et al.
Publicado: (2021)

Screening of interferon-stimulated genes against avian reovirus infection and mechanistic exploration of the antiviral activity of IFIT5
por: Wang, Sheng, et al.
Publicado: (2022)

NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages
por: Hong, Sun Mi, et al.
Publicado: (2022)

eNAMPT/TLR4 inflammatory cascade activation is a key contributor to SLE Lung vasculitis and alveolar hemorrhage
por: Tumurkhuu, Gantsetseg, et al.
Publicado: (2022)

The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes
por: Ahmed, Mohamed, et al.
Publicado: (2023)

Proteomic Analysis of Paracoccidioides brasiliensis During Infection of Alveolar Macrophages Primed or Not by Interferon-Gamma
por: Chaves, Edilânia Gomes Araújo, et al.
Publicado: (2019)

Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT–NAD(+)–SIRT1 pathway
por: Ma, Rui, et al.
Publicado: (2019)

Interferon Control of the Sterol Metabolic Network: Bidirectional Molecular Circuitry-Mediating Host Protection
por: Robertson, Kevin A., et al.
Publicado: (2016)

Regulation of Regenerative Periodontal Healing by NAMPT
por: Nokhbehsaim, Marjan, et al.
Publicado: (2013)

Visfatin/Nampt: An Adipokine with Cardiovascular Impact
por: Romacho, Tania, et al.
Publicado: (2013)

Zinc Finger CCCH-Type Antiviral Protein 1 Restricts the Viral Replication by Positively Regulating Type I Interferon Response
por: Zhang, Baoge, et al.
Publicado: (2020)

EGFR Activation Impairs Antiviral Activity of Interferon Signaling in Brain Microvascular Endothelial Cells During Japanese Encephalitis Virus Infection
por: Zhang, Ya-Ge, et al.
Publicado: (2022)

Association of Nicotinamide Phosphoribosyltransferase (NAMPT) Gene Polymorphisms and of Serum NAMPT Levels with Dilated Cardiomyopathy in a Chinese Population
por: Dou, Qingyu, et al.
Publicado: (2015)

Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb
por: Ahmed, Mohamed, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_45k76nfpokmp53agmp5qapa155