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Estimation of clinical trial success rates and related parameters

Previous estimates of drug development success rates rely on relatively small samples from databases curated by the pharmaceutical industry and are subject to potential selection biases. Using a sample of 406 038 entries of clinical trial data for over 21 143 compounds from January 1, 2000 to Octobe...

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Detalles Bibliográficos
Autores principales: Wong, Chi Heem, Siah, Kien Wei, Lo, Andrew W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409418/
https://www.ncbi.nlm.nih.gov/pubmed/29394327
http://dx.doi.org/10.1093/biostatistics/kxx069