Freeze-Dried Lopinavir-Loaded Nanostructured Lipid Carriers for Enhanced Cellular Uptake and Bioavailability: Statistical Optimization, in Vitro and in Vivo Evaluations

Nanostructured lipid carriers (NLCs) loaded with lopinavir (LPV) were prepared by the high-shear homogenization method. The LPV-NLCs formulations were freeze-dried using trehalose as a cryoprotectant. In vitro release studies in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8...

Descripción completa

Detalles Bibliográficos
Autores principales: Khan, Arshad Ali, Mudassir, Jahanzeb, Akhtar, Safia, Murugaiyah, Vikneswaran, Darwis, Yusrida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410192/
https://www.ncbi.nlm.nih.gov/pubmed/30823545
http://dx.doi.org/10.3390/pharmaceutics11020097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410192/
https://www.ncbi.nlm.nih.gov/pubmed/30823545
http://dx.doi.org/10.3390/pharmaceutics11020097

Ejemplares similares