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Freeze-Dried Lopinavir-Loaded Nanostructured Lipid Carriers for Enhanced Cellular Uptake and Bioavailability: Statistical Optimization, in Vitro and in Vivo Evaluations

Nanostructured lipid carriers (NLCs) loaded with lopinavir (LPV) were prepared by the high-shear homogenization method. The LPV-NLCs formulations were freeze-dried using trehalose as a cryoprotectant. In vitro release studies in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8...

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Detalles Bibliográficos
Autores principales:	Khan, Arshad Ali, Mudassir, Jahanzeb, Akhtar, Safia, Murugaiyah, Vikneswaran, Darwis, Yusrida
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410192/ https://www.ncbi.nlm.nih.gov/pubmed/30823545 http://dx.doi.org/10.3390/pharmaceutics11020097

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