Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis

Osteomyelitis is a chronic bone infection that is often treated with adjuvant antibiotic-impregnated poly(methyl methacrylate) (PMMA) cement spacers in multi-staged revisions. However, failure rates remain substantial due to recurrence of infection, which is attributed to the poor performance of the...

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Detalles Bibliográficos
Autores principales: Trombetta, Ryan P., Ninomiya, Mark J., El-Atawneh, Ihab M., Knapp, Emma K., de Mesy Bentley, Karen L., Dunman, Paul M., Schwarz, Edward M., Kates, Stephen L., Awad, Hani A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410209/
https://www.ncbi.nlm.nih.gov/pubmed/30813284
http://dx.doi.org/10.3390/pharmaceutics11020094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410209/
https://www.ncbi.nlm.nih.gov/pubmed/30813284
http://dx.doi.org/10.3390/pharmaceutics11020094

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