Five computational developability guidelines for therapeutic antibody profiling

Therapeutic mAbs must not only bind to their target but must also be free from “developability issues” such as poor stability or high levels of aggregation. While small-molecule drug discovery benefits from Lipinski’s rule of five to guide the selection of molecules with appropriate biophysical prop...

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Detalles Bibliográficos
Autores principales: Raybould, Matthew I. J., Marks, Claire, Krawczyk, Konrad, Taddese, Bruck, Nowak, Jaroslaw, Lewis, Alan P., Bujotzek, Alexander, Shi, Jiye, Deane, Charlotte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410772/
https://www.ncbi.nlm.nih.gov/pubmed/30765520
http://dx.doi.org/10.1073/pnas.1810576116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410772/
https://www.ncbi.nlm.nih.gov/pubmed/30765520
http://dx.doi.org/10.1073/pnas.1810576116

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