Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities

Endometrioid endometrial carcinomas (EECs) carry multiple driver mutations even when they are low grade. However, the biological significance of these concurrent mutations is unknown. We explored the interactions among three signature EEC mutations: loss-of-function (LOF) mutations in PTEN, gain-of-...

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Detalles Bibliográficos
Autores principales: Terakawa, Jumpei, Serna, Vanida Ann, Taketo, Makoto Mark, Daikoku, Takiko, Suarez, Adrian A., Kurita, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410785/
https://www.ncbi.nlm.nih.gov/pubmed/30782821
http://dx.doi.org/10.1073/pnas.1814506116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410785/
https://www.ncbi.nlm.nih.gov/pubmed/30782821
http://dx.doi.org/10.1073/pnas.1814506116

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