DNA polymerase θ accomplishes translesion synthesis opposite 1,N(6)-ethenodeoxyadenosine with a remarkably high fidelity in human cells

Here we show that translesion synthesis (TLS) opposite 1,N(6)-ethenodeoxyadenosine (εdA), which disrupts Watson–Crick base pairing, occurs via Polι/Polζ-, Rev1-, and Polθ-dependent pathways. The requirement of Polι/Polζ is consistent with the ability of Polι to incorporate nucleotide opposite εdA by...

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Detalles Bibliográficos
Autores principales: Yoon, Jung-Hoon, Johnson, Robert E., Prakash, Louise, Prakash, Satya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411006/
https://www.ncbi.nlm.nih.gov/pubmed/30808656
http://dx.doi.org/10.1101/gad.320531.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411006/
https://www.ncbi.nlm.nih.gov/pubmed/30808656
http://dx.doi.org/10.1101/gad.320531.118

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