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Increased Cystatin F Levels Correlate with Decreased Cytotoxicity of Cytotoxic T Cells
BACKGROUND: Cystatin F is a protein inhibitor of cysteine peptidases, expressed predominantly in immune cells and localised in endosomal/lysosomal compartments. In cytotoxic immune cells cystatin F inhibits both the major pro-granzyme convertases, cathepsins C and H that activate granzymes, and cath...
Autores principales: | Prunk, Mateja, Nanut, Milica Perisic, Sabotic, Jerica, Svajger, Urban, Kos, Janko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411024/ https://www.ncbi.nlm.nih.gov/pubmed/30840596 http://dx.doi.org/10.2478/raon-2019-0007 |
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