Cargando…
Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome
Centrosome amplification (CA) is a common feature of human tumours and a promising target for cancer therapy. However, CA’s pan-cancer prevalence, molecular role in tumourigenesis and therapeutic value in the clinical setting are still largely unexplored. Here, we used a transcriptomic signature (CA...
Autores principales: | de Almeida, Bernardo P., Vieira, André F., Paredes, Joana, Bettencourt-Dias, Mónica, Barbosa-Morais, Nuno L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411098/ https://www.ncbi.nlm.nih.gov/pubmed/30856170 http://dx.doi.org/10.1371/journal.pcbi.1006832 |
Ejemplares similares
-
Patterns of selection against centrosome amplification in human cell lines
por: Dias Louro, Marco António, et al.
Publicado: (2021) -
Centrosome Remodelling in Evolution
por: Ito, Daisuke, et al.
Publicado: (2018) -
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis
por: Lopes, Carla A.M., et al.
Publicado: (2018) -
Q&A: Who needs a centrosome?
por: Bettencourt-Dias, Mónica
Publicado: (2013) -
Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
por: Marteil, Gaëlle, et al.
Publicado: (2018)