TAK-071, a muscarinic M(1) receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys

Activation of the muscarinic M(1) receptor is a promising approach to improve cognitive deficits associated with cholinergic dysfunction in Alzheimer’s disease, dementia with Lewy bodies, and schizophrenia. TAK-071 is an M(1)-selective positive allosteric modulator that improves cognitive deficits i...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurimoto, Emi, Nakashima, Masato, Kimura, Haruhide, Suzuki, Motohisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411103/
https://www.ncbi.nlm.nih.gov/pubmed/30856192
http://dx.doi.org/10.1371/journal.pone.0207969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411103/
https://www.ncbi.nlm.nih.gov/pubmed/30856192
http://dx.doi.org/10.1371/journal.pone.0207969

Ejemplares similares