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TAK-071, a muscarinic M(1) receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys
Activation of the muscarinic M(1) receptor is a promising approach to improve cognitive deficits associated with cholinergic dysfunction in Alzheimer’s disease, dementia with Lewy bodies, and schizophrenia. TAK-071 is an M(1)-selective positive allosteric modulator that improves cognitive deficits i...
Autores principales: | Kurimoto, Emi, Nakashima, Masato, Kimura, Haruhide, Suzuki, Motohisa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411103/ https://www.ncbi.nlm.nih.gov/pubmed/30856192 http://dx.doi.org/10.1371/journal.pone.0207969 |
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