Diverse and cancer type-specific roles of the p53 R248Q gain-of-function mutation in cancer migration and invasiveness

Gain-of-function (GOF) mutations in the TP53 gene lead to acquisition of new functions by the mutated tumor suppressor p53 protein. A number of the over-represented ‘hot spot’ mutations, including the ones in codons 175, 248 or 273, convey GOF phenotypes. Such phenotypes may include resistance to ch...

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Detalles Bibliográficos
Autores principales: Olszewski, Maciej Boleslaw, Pruszko, Magdalena, Snaar-Jagalska, Ewa, Zylicz, Alicja, Zylicz, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411346/
https://www.ncbi.nlm.nih.gov/pubmed/30968154
http://dx.doi.org/10.3892/ijo.2019.4723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411346/
https://www.ncbi.nlm.nih.gov/pubmed/30968154
http://dx.doi.org/10.3892/ijo.2019.4723

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