Anti-apoptotic Mutations Desensitize Human Pluripotent Stem Cells to Mitotic Stress and Enable Aneuploid Cell Survival

Human pluripotent stem cells (hPSCs) are susceptible to numerical and structural chromosomal alterations during long-term culture. We show that mitotic errors occur frequently in hPSCs and that prometaphase arrest leads to very rapid apoptosis in undifferentiated but not in differentiated cells. hPS...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Hirst, Adam J., Duan, Fuyu, Qiu, Hui, Huang, Rujin, Ji, Ying, Bai, Lufeng, Zhang, Fengzhi, Robinson, Darren, Jones, Mark, Li, Le, Wang, Peizhe, Jiang, Peng, Andrews, Peter W., Barbaric, Ivana, Na, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411485/
https://www.ncbi.nlm.nih.gov/pubmed/30773485
http://dx.doi.org/10.1016/j.stemcr.2019.01.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411485/
https://www.ncbi.nlm.nih.gov/pubmed/30773485
http://dx.doi.org/10.1016/j.stemcr.2019.01.013

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