Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells

The important role of insulin-like growth factor-1 receptor (IGF-1R) in tumorigenesis has been well established. The classical model involves IGF-1R binding to IGF-1/2, the following activation of PI3K-Akt-signaling cascades, driving cell proliferation and apoptosis inhibition. Here we report a new...

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Detalles Bibliográficos
Autores principales: Wang, Shu-Qing, Yang, Xiang-Yu, Yu, Xin-Feng, Cui, Shu-Xiang, Qu, Xian-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411632/
https://www.ncbi.nlm.nih.gov/pubmed/30861413
http://dx.doi.org/10.1016/j.omtn.2019.02.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411632/
https://www.ncbi.nlm.nih.gov/pubmed/30861413
http://dx.doi.org/10.1016/j.omtn.2019.02.008

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