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Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells
The important role of insulin-like growth factor-1 receptor (IGF-1R) in tumorigenesis has been well established. The classical model involves IGF-1R binding to IGF-1/2, the following activation of PI3K-Akt-signaling cascades, driving cell proliferation and apoptosis inhibition. Here we report a new...
Autores principales: | Wang, Shu-Qing, Yang, Xiang-Yu, Yu, Xin-Feng, Cui, Shu-Xiang, Qu, Xian-Jun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411632/ https://www.ncbi.nlm.nih.gov/pubmed/30861413 http://dx.doi.org/10.1016/j.omtn.2019.02.008 |
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