Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

Adenosine triphosphate (ATP) plays fundamental roles in cellular biochemistry and was recently discovered to function as a biological hydrotrope. Here, we use mass spectrometry to interrogate ATP-mediated regulation of protein thermal stability and protein solubility on a proteome-wide scale. Therma...

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Detalles Bibliográficos
Autores principales: Sridharan, Sindhuja, Kurzawa, Nils, Werner, Thilo, Günthner, Ina, Helm, Dominic, Huber, Wolfgang, Bantscheff, Marcus, Savitski, Mikhail M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411743/
https://www.ncbi.nlm.nih.gov/pubmed/30858367
http://dx.doi.org/10.1038/s41467-019-09107-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411743/
https://www.ncbi.nlm.nih.gov/pubmed/30858367
http://dx.doi.org/10.1038/s41467-019-09107-y

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